Publications

 

SCIENTIFIC PUBLICATIONS

 

 

1.         Gentz, R., Langner, A., Chang, A.C.Y, Cohen, S.N., Bujard, H. (1981).  Cloning and analysis of strong promoters is made possible by the downstream placement of a termination signal. Proc. Natl. Acad. Sci. USA 78, 4936-4940.

 

2.         Bujard, H., Niemann, A., Breunig,, K., Roisch, U., Dresel, A., von Gabain, A., Gentz, R., Stüber, D. and Weiher, H. (1982).  The interaction of E.coli  RNA polymerase  with promoters of high signal strength. In: Promoters- structure and function. Chamberlin, M. and Rodriguez, R. (eds.) Praeger Scientific N.Y., pp. 121 – 140.

 

3.         Bujard, H., Baldari, C., Brunner, M., Deuschle, U., Gentz, R., Hughes,  J., Kammerer, W., and Stüber, D. (1983). Integration of efficient promoters of the E.coli system into plasmid vectors. In: Gene amplification and analysis, vol. 3. Expression of cloned genes in procaryotic and eukaryotic cells. Papas, T.S., Rosenberg, M. and Chirikjian, J.G. (eds.) Elsevier New York-Amsterdam-Oxford, pp 65-87.

 

4.         Bujard, H., Deuschle, U., Kammerer, W., Gentz, R., Bannwarth W. and Stüber, D. (1985). Promoters of the E.coli system. In vivo strength and the contribution of elements in the transcribed region. In: Sequence Specificity in Transcription and Translation (R. Calendar and L. Gold, Eds.). UCLA Symposium on Molecular and Cellular Biology, New Series, Vol. 30 ARL Inc., New York, pp. 21-29.

 

5.         Bujard, H., Stüber, D., Gentz, R., Deuschle, U. and Peschke, U. (1985). Insertion of transcriptional elements outside the replication region can interfere with replication, maintenance and stability of Col E1-derived plasmids. In: Plasmids in Bacteria (D.R. Helinski, S.N. Cohen, D.-B. Clewell, D.A. Jackson, A. Hollaender, Eds.), Plenum Press, New York, pp. 45-52.

 

6.         Gentz, R. and Bujard, H. (1985). Promoters recognized by Escherichia coli polymerase selected by function: Highly efficient promoters from bacteriophage T5. J. Bacteriology 10, 70-77.

 

7.         Peschke, U., Beuck, V., Bujard, H., Gentz, R. and Le Grice, S. (1985). Efficient utilization of Escherichia coli transcriptional signals in Bacillus subtilis. J. Mol. Biol. 186, 547-555.

 

8.         Certa, U., Bannwarth, W., Stüber, D., Gentz, R., Lanzer, M., Le Grice, S., Guillot, F., Wendler, I., Hunsmann, G., Bujard, H. and Mous, J. (1986). Subregions of a conserved part of the HIV gp41 transmembrane protein are differentially recognized by antibodies of infected individuals.  EMBO J. 5, 3051-3056.

 

9.         Deuschle, U., Gentz, R. and Bujard, H. (1986). Lac repressor blocks transcribing RNA polymerase and terminates transcription. Proc. Natl. Acad. Sci. USA 83, 4134-4137.

 

10.      Deuschle, U., Kammerer, W., Gentz, R. and Bujard, H. (1986). Promoters of Escherichia coli: A hierarchy of in vivo strength indicates alternate structures. EMBO J. 5, 2987-2994.

 

11.       Kammerer, W., Deuschle, U., Gentz, R. and Bujard, H. (1986). Functional dissection of Escherichia coli promoters: Information in the transcribed region is involved in late steps of the overall process. EMBO J. 5, 2995-3000.

 

12.       Le Grice, S., Gentz, R., Peschke, U., Stüber, D., and Bujard, H. (1986). Intergenic utilization of Escherichia coli transcriptional signals. In: Bacillus Molecular Genetics and Biotechnology Applications (A.T. Ganesan and J. Hoch, Eds.), Academic Press, New York, pp. 433-445.

 

13.       Bujard, H., Gentz, R., Lanzer, M., Stüber, D., Müller, M., Ibrahimi, I., Häuptle, M.-T. and Dobberstein, B. (1987). A T5 promoter based transcription-translation system for the analysis of proteins in vitro and in vivo. Methods in Enzymology 155, 416-433.

 

14.       Ibrahimi, I. and Gentz, R. (1987). A functional interaction between the signal peptide and translation apparatus is detected by the use of a single point mutation which blocks translocation across mammalian endoplasmic reticulum. J. Biol. Chem. 262, 10189-10194.

 

15.       Le Grice, S.F.J., Gentz, R., Bannwarth, W. and Kocher, H.P. (1987). Pseudosecretion of Escherichia coli chloramphenicol acetyl transferase by Bacillus subtilis. J. Bacteriology 169, 3362-3364.

 

16.       Garotta, G., Ozmen, L., Döbeli, H., Gentz, R., LeGrice, S., Bannwarth, W., Hochuli, E., Talmadge, K. (1987). Analysis of structure and function of human IFNγ.  J. Interferon Res. 7, 685.

 

17.       Certa, U., Matile, H., Gentz, R., Tanabe, K. and Scaife, J. (1988). Genetic polymorphism of Plasmodium falciparum surface antigens. Trop. Geo. Med. 40, 178.

 

18.       Döbeli, H., Gentz, R., Jucker, W., Garotta, G., Hartmann, D.W. and Hochuli, E. (1988). Role of the carboxy-terminal sequence on the biological activity of human immune interferon (IFNγ). J. Biotechnol. 6, 199-216.

 

19.       Gentz, R., Certa, U., Takacs, B., Matile, H., Döbeli, H., Pink, R., Mackay, M., Bone, N. and Scaife, J.G. (1988). Major surface antigen p190 of Plasmodium falciparum:  Detection of common epitopes present in a variety of plasmodia isolates. EMBO J. 7, 225-230.

 

20.       Gentz, R., Kuys, Y., Zwieb, C., Taatjes, D., Taatjes, H., Bannwarth, W., secretion of  three chimeric polypeptides Stüber, D. and Ibrahimi, I. (1988).  Association of degradation and secretion of  three chimeric polypeptides in Escherichia coli.

J. Bacteriol. 170, 2212-2220.

 

21.       Hochuli, E., Bannwarth, W., Döbeli, H., Gentz, R. and Stüber, D. (1988). Genetic approach to facilitate purification of recombinant proteins with a novel metal chelate adsorbent. Bio/Technology 11, 1321-1325.

 

22.       Takacs, B., Certa, U., Crisanti, A., Gentz, R., Etlinger, H., Jacot, H., Matile, H., Pink, J.R.L. and Sinigaglia, F. (1988). Non-polymorphic sequences of the major surface antigen, p190, from P. falciparum merozoites. In: “Technological Advances in Vaccine Development “

R. Lasky, Ed.), Vol. 84, A.R. Liss Inc., New York, pp. 57-73.

 

23.       Ozmen, L., Fountoulakis, M., van Loon, A.P.G.M., Gentz, R., and Garotta, G. (1988). Importance of the carboxy-terminal end of human IFNγ for its binding to the receptor. Lymphokine Res., 7, 328, 1988

 

24.       Caspers, P., Gentz, R., Matile, H., Pink, J.R.L. and Sinigaglia, F. (1989). The circumsporozoite gene from NF54, a Plasmodium falciparum isolate used in malaria vaccine trials. Mol. Biochem. Parasitolopgy. 35, 185-190.

 

25.       Cohen, D.R., Ferreira, P.C.P., Gentz, R., Franza, Jr., B.R. and Curran, T. (1989). The product of a Fos-related gene fra-1 binds cooperatively to the Ap1 site with Jun: Transcription factor Ap1 is comprised of multiple protein complexes. Genes and Development 3, 173-184.

 

26.       Gentz, R., Chen, C.-H.  and  Rosen, C.A. (1989). Bioassay for transactivation using purified human immunodeficiency virus tat-encoded protein: transactiviation requires mRNA synthesis.  Proc. Natl. Acad. Sci. USA 86, 821-824.

 

27.       Gentz, R., Rauscher III, F.J., Abate, C. and Curran, T. (1989). Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains. Science 243, 1695-1699.

 

28.       Pink, J.R.L., Caspers, P., Certa, U., Etlinger, H., Gentz, R., Gillessen, D., Guttinger, M., Jacot, H., Matile, H., Sinigaglia, F., Stürchler, D., Stüber, D. and Takacs, B. (1989). Progress towards a malaria vaccine. In: Rapid Methods and Automation in Microbiology and Immunology, (A. Balows, R.C. Tilton and A. Turano, Eds.) Brixia Academic Press, Brescia, Italy, pp. 36-44.

 

29.       Abate, C., Luk, D., Gentz, R., Rauscher III, F.J. and Curran, T. (1990). Expression and purification of the leucine zipper and DNA binding domains of Fos and Jun: Both Fos and Jun contact DNA directly.  Proc. Natl. Acad. Sci. USA 87, 1032-1036.

 

30.       Abate, C., Rauscher III, F.J., Gentz, R. and Curran, T. (1990). Fos and Jun interact through a structural motif reminiscent of a coiled-coil structure. UCLA Symposium on Molecular and Cellular Biology, New Series, Vol. 114. “Genetic Mechanisms in Carcinogenesis and Tumor Progression” (C.C. Harris and L.A.. Liotta, Eds.), Wiley-Liss Inc., New York, p. 1-13.

 

31.       Dembic, Z., Lötscher, H.R., Gubler, U., Pan, Y.-C.E., Lahm, H.W., Gentz, R., Brockhaus, M. and Lesslauer, W. (1990). Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences. Cytokine 2, 231-237.

 

32.       Lötscher, H., Pan, Y.C.E., Lahm, H.W., Gentz, R., Brockhaus, M., Tabuchi, H. and Lesslauer, W. (1990). Molecular cloning and expression of the human 55kDa TNF receptor. Cell 61, 351-360.

 

33.       Rauscher III, F.J., Abate, C., Gentz, R. and Curran, T. (1990). Fos and Jun dimerize via a leucine zipper and bind cooperatively to the AP-1 site. UCLA Symposium on Molecular and Cellular Biology, New Series Vol. 132, Molecular Biology of the Cardiovascular System (R. Roberts and M.D. Schneider, Eds.), Alan R. Liss Inc., New York, pp. 143-153.

 

34.       Lesslauer, W., Brockhaus,  M., Pan, Y.-C.E., Lahm, H.W., Gubler, U., Dembic, Z., Gentz, R., Tabuchi, H. and Lötscher, H. (1991). Two human TNF receptors: Biochemical characterisation and molecular cloning. In: Cellular and Cytokine Networks in Tissue Immunity (Meltzer, M. and Mantovani, A., eds.). J. Wiley & Sons, Inc., 325 – 330.

 

35.     Fountoulakis, M., Schlaeger, E.J., Gentz, R., Juranville, J.F., Manneberg, M. Ozmen, L. and Garotta, G. (1991). Purification and biochemical characterization of a soluble mouse interferon γ receptor produced in insect cells. Eur. J.  Biochemistry 198, 441-450.

 

36.       Lesslauer, W., Brockhaus, M., Pan, Y.-C.E., Lahm, H.-W., Gubler, U., Dembic, Z., Gentz, R., Tabuchi, H. and Lötscher, H. (1991). Two human TNF receptors: Biochemical characterization and molecular cloning. In: “International Conference on leukocyte Biology”. Cellular and Cytokine Networks in Tissue Immunity, Wiley-Liss, Inc. 325-330.

 

37.       Lötscher, H., Brockhaus, M., Dembic, Z., Gentz, R., Gubler, U., Hohmann, H.-P., Lahm, H.-W., van Loon, A.P.G.M., Pan, Y.-C.E., Schläger, E.-J., Steinmetz, M., Tabuchi, H. and Lesslauer, W. (1991). Two distinct tumor necrosis factor receptors – members of a new cytokine receptor gene family. Oxford Surveys on Eukaryotic Genes, Vol. 7, 119-142.

 

38.       Ozmen, L., Gentz, R., Fountoulakis, M., Blüthmann, H., Stüber, D. and Garotta, G. (1991). Preliminary characterization of the soluble IFNγ receptor as an immunomodulatory agent. J. Chemotherapy, Vol. III, 99-102.

 

39.       Rothe, J.G., Brockhaus, M., Gentz, R. and Lesslauer, W. (1991).  Molecular cloning and expression of the mouse Tnf receptor type b  Immunogenetics, 34, 338-340.

 

40.       Loetscher, H., Gentz, R., Zulauf, M., Lustig, A.,,Tabuchi, H., Schlaeger, E-J., Brockhaus, M., Gallati, H., Manneberg, M. and Lesslauer, W  (1991). Recombinant 55 kDa TNF receptor: Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity. J. Biol. Chem., 266, 18324-18329.

 

41.       Lesslauer, W., Tabuchi, H., Gentz, R., Brockhaus, M., Schlaeger, E.J., Grau, G., Piguet, P.F., Pointaire, P., Vassalli, P, and Loetscher, H. (1991) Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality.

Eur. J. Immunol. 21, 2883-2886.

 

42.       Loetscher, H., Brockhaus, M., Dembic, Z., Gallati, H., Gentz, R., Gubler, U., Lahm, H.-W., Lustig, A., Pan, Y.C., Schlaeger, E.J., Tabuchi, H., Zulauf, M. and Lesslauer, W. (1992)  Biochemical and molecular characterization of TNF receptors/TNF-like receptors: Two distinct human TNF receptors: purification, molecular cloning and expression, in: Tumor necrosis factor: Structure – Function relationship and clinical application. Osawa, T. and Bonavida B., eds. (Basel: Karger), pp 34 – 46.

 

43.       Gehr, G., Gentz, R., Brockhaus, M., Loetscher, H. and Lesslauer, W. (1992). Both Tumor necrosis factor receptors types mediate proliferation signals in human mononuclear cell activation.

J. of Immunology, 149, 311-317.

 

44.       Fountoulakis, M. and Gentz, R. (1992) Effect of glycosylation on the properties of soluble interferon gamma receptors produced in procaryotic and eukaryotic expression systems. Biotechnology, October, 1143 – 1147.

 

45.       Grzesiek, S., Döbeli, H., Gentz, R., Gianni, G., Labhardt, A.M. and Bax, A. (1992). 1H, 13C, and 15N NMR backbone assignements and secondary structure of human interferon gamma. Biochemistry 31, 8180-8190.

 

46.       Piguet, P.F., Grau, G.E., Vesin, C., Löetscher, H., Gentz, R. and Lesslauer, W. (1992). Evolution of the collagen arthritis in mice is arrested by treatment with anti TNF antibody or a recombinant soluble TNF receptor. Immunology 77, 510-514.

 

47.       Gentz, R., Hayes, A., Grau, N., Fountoulakis, M., Lahm, L., Ozmen, L. and Garotta, G. (1992) Analysis of soluble human and mouse interferon γ receptors expressed in eukaryotic cells. Eur. J. of Biochemistry, 210, 545-554.

 

48.       Ozmen, L., Fountoulakis, M., Gentz, R., and Garotta, G. (1993) Immunomodulation with soluble IFNγ receptor:  preliminary study. In: International review of experimental pathology (Ryffel, B. ed.), vol. 34B, Academic Press Inc., Orlando, FL, pp 137-147.

 

49.       D’Arcy, A., Banner, D.W., Janes, W., Winkler, F.K., Loetscher, H., Schönfeld, H.-J., Zulauf, M., Gentz, R. and Lesslauer, W. (1993). Crystallization and preliminary crystallographic analysis of TNFβ and a TNFβ/55kDa TNF receptor complex.  J. of Molelcular .Biololgy, 229, 555 – 557.

 

50.       Kalina, U., Ozmen, L., Padova, K., Gentz, R.  and  Garotta, G. (1993).  The human IFNγ receptor accessory factor encoded by chromosome 21 transduces the signal for the induction of 2′,5′-A-oligo-synthetase, resistance to virus cytopathic effect and MHC class I antigens.

J. of Virology, 67, 1702 – 1706.

 

51.       Rothe, J., Blüthmann, H., Gentz, R., Lesslauer, W. and Steinmetz, M. (1993). Genomic organization and promoter function of the murine tumor necrosis factor receptor β gene. Molecular Immunology, 30, No.2, 165-175.

 

52.       Van Ostade, X., Vandenabeele, P., Everaerdt, B., Loetscher, H., Gentz, R., Brockhaus, M., Lesslauer, W., Tavernier, J., Brouckaert, P. and Fiers, W. (1993).  Human TNF mutants with selective activity on the p55 receptor. Nature, 361, 266-269.

 

53.       Ozmen, L., Gribaudo, G., Fountoulakis, M., Gentz, R., Landolfo S. and Garotta, G. (1993) Mouse soluble IFNγ receptor as IFNγ inhibitor: Distribution, antigenicity and activity after injection in mice. J. Immunology, 150, 2698 – 2705.

 

54.       Banner, D.W., D’Arcy, A., Janes, W., Gentz, R., Schoenfeld, H.-J., Loetscher, H. and Lesslauer, W. (1993). Crystal structure of the soluble human  55 kDa TNF receptor/human TNFβ complex. Implications for TNF receptor activation. Cell, 73, 431 – 445.

 

55.       Novelli, F., Giovarelli, M., Gentz, R., Zucca, M., di Pierro, F., Garotta, G. and Forni, G. (1993). Modulation of interferon-γ receptor during human T lymphocyte alloactivation. Eur. J. Immunol. 23, 1226-1231.

 

56.       Crowe, J., Döbeli, H., Gentz, R., Hochuli, E., Stüber, D., and Henco, K. (1994) 6xHis-Ni-NTA chromoatography as a superior technique in recombinant protein expression/purification. Methods in Molecular Biology, 31, 371-387.

 

57.       Schmid, G., Wild, N., Fountoulakis, M., Gallati, H., Gentz, R., Ozmen, L., and Garotta, G. Production and characterization of soluble mouse and human IFNγ receptors (IFNγR) from insect cells. In: Animal Cell Technology:  Products of Today, Prospects for Tomorrow. R.E. Spier et al. eds., Butterworth-Heinemann, Oxford.

 

58.       Feng, G., Ouyang, Y., Hu, D., Shi, Z., Gentz, R. and Ni. J. (1996) Grap is a Novel SH3-SH2-SH3 Adaptor Protein That Couples Tyrosine Kinases to the Ras Pathway. J. Biol. Chem. 271, 12129-12132.

 

59.       Muzio, M., Chinnaiyan, A., Kischkel, F., O’Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J., Zhang, M., Gentz, R., Mann, M., Krammer, P., Peter, M. and Dixit, V.  (1996) FLICE, a Novel FADD-Homologous ICE/CED-3-like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex. Cell, 85, 817-827.

 

60.       Chinnaiyan, A., O’Rourke, K., Yu, G., Lyons, R., Garg, M., Duan, D., Zing, L., Gentz, R., Ni, J. and Dixit, V. (1996) Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95. Science 274, 990-992.

 

61.       Mathews, S., Döbeli, H., Pruschy, M., Bosser, R., D’Arcy, A., Oefner, C., Zulauf, M., Gentz, R., Breu, V., Matile, H., Schlaeger, J., and Fischli, W. (1996). Recombinant Human Renin Produced in Different Expression Systems: Biochemical Properties and 3D Structure. Protein Expression and Purification 7, 81-91.

 

62.       Pan, G., O’Rourke, K., Chinnaiyan, A.M., Gentz, R., Ebner, R., Ni, J., Dixit, V.M.  (1997) The  Receptor for the Cytotoxic Ligand TRAIL. Science, 276, 111-113.

 

63.       Coleman, T., Huddleston, K., Ruben, S., Rosen, C. and Gentz, R.  (1997) Expression and Reconstitution of NF-kB from Insect Cells Using a Baculovirus Vector.  Protein Expression and Purification 9, 40-48.

 

64.       Ni., J., Abrahamson, M., Zhang, M., Fernandez, M., Grubb, A., Su, J., Yu, G., Li, Y., Parmelee, D., Xing, L., Coleman, T., Lima, S., Thotakura, R., Hesselberg, M. and Gentz, R. (1997) Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. J. Biol. Chem. 272, 10853-10858.

 

65.       Kwon, B., Oh, K., Lee, Z., Kim, K., Kim, M., Ni, J., Gentz, R., Yu, G., Young, P., Truneh, A., Harrop, J., Lyn, S. and Tan, K. (1997) A newly identified member of tumor necrosis factor receptor superfamily shows a wide tissue distribution with multiple forms and T cell stimulatory activities. J. Biol. Chem. 272, 14272-14276.

 

66.       Patel, V., Kreider, B., Li, Y., Li, H., Leung, K., Salcedo, T., Nardelli, B., Gentz, S., Thotakura, R., Parmelee, D., Gentz, R. and Garotta, G. (1997) Molecular and Functional Characterization of two Novel Human C-C Chemokines as Inhibitors of Two Distinct Classes of Myeloid Progenitors.  J. Exp. Med. 185, 1163-1172.

 

67.       Coleman, T., Parmelee, D., Thotakura, N., Nguyen, N., Burgin, M., Gentz, S. and Gentz, R. (1997). Production and purification of novel secreted human proteins. Gene. 190, 163-171.

 

68.       Hu, S., Vincenz, C., Ni, J., Gentz, R., Dixit, V.M. (1997). I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.  J. Biol. Chem. 272, 17255-17257.

 

69.       Shi, E.Y., Ni, J., Xiao, G., Liu, Y.E., Fuchs, A., Yu, G., Su, J., Cosgrove, J.M., Xing, L., Zhang, M., Li, J., Aggarwal, B.B., Meager, A., Gentz, R.  (1997)  Antitumor Activity of the Novel Human Breast Cancer Growth Inhibitor, Mammary-derived Growth Inhibitor-related Gene, MRG1. Cancer Research 57, 3084-3091.

 

70.       Hu, J.S., Hastings, G.A., Cherry, S., Gentz, R., Ruben, S., Coleman, T.A.  (1997)  A novel regulatory function of proteolytically cleaved VEGF-2 for vascular endothelial and smooth muscle cells. FASEB J 11, 498-504.

 

71.       Zeng, Z., Parmelee, D., Hyaw, H., Coleman T.A., Su, K., Zhang, J., Gentz, R., Ruben, S., Rosen, C., Li, Y. (1997). Cloning and characterization of a novel human DNase. Biochem. Biophys. Res. Commun. 231, 499-504.

 

72.       Pan, G., Ni, J., Wei, Y.F., Yu, G., Gentz, R., Dixit, V.M.  (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277, 815-818.

 

73.       Fernandes, A.P., Herrera, E.C., Mayrink, W., Gazzinelli, R.T., Liu, W.Y., de Costa, C.A., Tavares, C.A., melo, M.N., Michalick, M.S., Gentz, R., Nascimento, E.  (1997) Immune responses induced by a Leishmania (Leishmania) amazonensis recombinant antigen in mice and lymphocytes from vaccinated subjects. Rev. Inst. Med. Trop. Sao Paulo 39, 71-78.

 

74.       van der Knaap, J.A., Borst, J.W.,  van der Vliet, P.C., Gentz, R.  and Timmers, H. M.  (1997) Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and mammals. Drosophila.  Proc. Natl. Acad. Sci. 94, 11827-11832.

 

75.       Zhang, J., Collins, A., Chen, M., Knyazev, I., Gentz, R. (1998) High-density perfusion culture of insect cells with a biosep ultrasonic filter. Biotech & Biotech Eng. 59, 351-359.

 

76.       Wang, C.Y., Ni, J., Jiang, T.A., Hsu, M., Dugich-Djordjevic, M., Feng, L., Zhang, M., Mei, L., Gentz, R., and Lu, B.  (1998) Cloning and characterization of glial cell line-derived neurotrophic factor receptor-B:  A novel receptor for members of glial cell line-derived neurotrophic factor family of neurotrophic factors. Neuroscience 83, 7-14.

 

77.       Zhang, J., Alfonso, P., Thotakura, N., Su, J., Buergin, M., Parmelee, D., Collins, A., Oelkuct, M., Gaffney, S., Gentz, S., Radman, D., Wagner, G., and Gentz, R. (1998) Expression, Purification, and Bioassay of Human Stanniocalcin from Baculovirus-Infected Insect Cells and Recombinant CHO Cells.  Protein Expression and Purification 12, 390-398.

 

78.      DeNiu, P., Olsen, H.S., Gentz, R., Wagner, G.F. (1998) Immunolocalization of stanniocalcin in human kidney. Mol. Cell Endocrinology 137(2), 155-159.

 

79.      Carvalho, A.F., Santos, J.R., Gentz, R., Bonjardim, C.A., Golgher, R.R.,    Ferreira, P.C., Kroon, E.G. (1998) Culture of human amniotic cells:  a system to study interferon production. Placenta 19, 307-314.

 

80.     Kwon, B.S., Wang, S., Udagawa, N., Haridas, V., Lee, Z.H., Kim, K.K., Oh, K., Greene, J., Li, Y., Su, J., Gentz, R., Aggarwal, B.B., Ni, Jian.  (1998)  TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB Jour. 12, 845-854.

 

81.      Langley, R., Leung, E., Morris, C., Berg, R., McDonald, M., Weaver, A., Parry, D., Ni, J., Su, J., Gentz, R., Spurr, N., and Krissansen, G.W.  (1998) Identification of Multiple Forms of 180-kDa Ribosome Receptor in Human Cells. DNA and Cell Bio, 17, 449-460.

 

82.     Zhai, Y, Guo, R., Hsu, T., Yu, G., Ni, J., Kwon, B., Jiang, G., Lu, J., Tan, J., Ugustus, M., Carter, K., Rojas, L., Zhu, F., Lincoln, C., Endress, G., Xing, L., Wang, S., Oh, K., Gentz, R., Ruben, S., Lippman, M., Hsieh, S., and Yang, D.  (1998) LIGHT, A novel ligand for lymphotoxin β receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J. Clin. Invest. 102, 1142-1151.

 

83.     Cornish, A., Freeman, S., Forbes, G., Ni, J., Zhang, M., Cepeda, M., Gentz, R., Augustus, M., Carter, K., and Crocker, P.  (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.  Blood, 92, 2123-2132.

 

84.     Ni, J., Fernandez, A.F., Danielsson, L., Chillakuru, R.A., Zhang, J., Grubb, A., Su, J., Gentz, R., and Abrahamson, M.  (1998) Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor. J. Biol. Chem, 273, 24797-24804.

 

85.      Kwon, B.S., Wang., S., Udagawa, N., Haridas, V., Lee, Z.H., Kim, K.K., Oh, K., Greene, J., Li, Y., Su, J., Gentz, R.,  Aggarwal, B.B., Ni, J.  (1998) TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption.  FASEB J, 12, 845-854.

 

86.     Zhai, Y., Ni, J., Jiang, G., Lu, J., Xing, L., Lincoln, C., Carter, K., Janat, F., Kozak, D., Xu, S., Rojas, L., Aggarwal, B., Ruben, S., Li, L., Gentz, R. and Yu, G.  (1999) VEGI, a novel cytokine of the tumor necrosis factor family, is an angio-genesis inhibitor that suppresses the growth of colon carcinomas in vivo. FASEB J, 13, 181-189.

 

87.      Navale, V., Kaushal, P., Hunt, S., Burducea, I., Gentz, R., Khan, F. and Vertes, A. (1999) Peptide mapping and disulfide bond analysis of myeloid progenitor inhibitory chemokine and keratinocyte growth factor by matrix-assisted laser desorption ionization mass spectrometry. Anal Biochemistry Feb 1, 267(1): 125-34.

 

88.      Kong, E., Chen, M., Gentz, R. and Zhang, J.  (1999) Cell growth and protein formation on various microcarriers.  Cytotechnology 29 (2):  149-156.

 

89.      Kong, D., Cardak, S., Chen, M., Gentz, R., & Zhang, J.  (1999) High cell density and productivity culture of Chinese hamster ovary cells in a fluidized bed bioreactor.  Cytotech. 29 (3), 215-220.

 

90.      Xiao, G., Lui, Y.E., Gentz, R., Sang, Q.A., Ni, J., Goldberg, I.D., Shi, Y.E.  (1999) Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial  cells.  Proc. Natl. Acad. Sci., U.S.A.  30; 96 (7), 3700-3705.

 

91.      Moore, P.A., Belvedere, O., Orr, A., Pieri, K., LaFleur, D.W., Feng, P., Soppet, D., Charters, M., Gentz, R., Parmelee, D., Li, Y., Galperina, O., Giri, J., Roschke, V., Nardelli, B., Carrell, J., Sosnovtseva, S., Greenfield, W., Ruben, S.M., Olsen, H.S., Fikes, J., Hibert, D.M.  (1999) BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.  Science 285 260-3.

 

92.         Deckers, M.L., Smits, P., Ni, J., Karperien, M., Tylzanowski, P., Feng, P., Parmelee, D., Zhang, J., Bouffard, E., Gentz, R., Lowik, C. and Merregaert, J.  (1999) Baculovirus expression of the human extracellular matrix protein I (Ecm1) and its effects on in vitro mineralization of embryonic metatarsals. I

 

93.      Campos, M.A., Kroon, E.G., Gentz, R., Ferreira, P.C.  (1999) Protein Domains involved in nuclear transport of Fos.  Cell Biol.  Int. 23(1): 91-88.

 

94.      Haridas V. Shrivastav A., Su J., Yu GL, Ni. J., Liu  D., Chen SF, Ni Y., Ruben SM, Gentz R., Aggarwal BB.  (1999) VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. Oncogene. 1999 Nov 11;18 (47):6496-504.

 

95.     Albert T.K., Lemaire, M., van Berkum, N.L., Gentz, R., Collart, M.A. and Timmers, H.TH.M. (2000) Isolation and characterization of human orthologs of yeast CCR4—NOT complex subunits.  Nucl. Acids. Res. 28(3): 809-817.

 

96.     Ni, J., Kalff-Suske, M., Gentz, R., Schageman, J., Beato, M. and Klug, J.  (2000) All human genes of the uteroglobin family are localized on chromosome 11q12.2 and form a dense cluster. Ann. N.Y. Acad. Sci. 923: 25-42.

 

97.     DeNiu,  P., Radman, DP., Jaworsk,i EM., Deol, H., Gentz, R., Su J., Olsen, HS, (2000). Development of a human stanniocalcin radioimmunoassay: serum and tissue hormone levels and pharmacokinetics in the rat. Mol Cell Endocrinol.162 (1-2) 131-44.

 

98.      Rajarathnam, K., Li, Y., Rohrer, T., Gentz, R., (2001) Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine.  J.  Biol. Chem. 276(7):4909-16.

 

99.      Deckers, MM., Smits, P., Karperien, M., Ni, J. Tylzanowski, P., Feng, P., Parmelee, D., Zhang, J., Bouffard, E., Gentz, R., Lowik, CW., Merregaert, J., (2001) Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro.  Bone.  28(1):14-20.

 

100.      Han, Z., Ni, J., Smits, P., Underhill,  CB., Zie, B., Chen, Y., Liu, N., Tylzanowsk,i P., Parmelee, D., Feng,  P., Ding, I., Gao, F., Gentz, R., Huylebroeck, D. (2001) Extracellular matrix protein 1 (ECMI) has angoigenic proterties and is expressed by breast tumor cells. FASEB 15(6):988-94.

 

101.     Oren, DA., Li, Y.,Volovik, Y., Morris, TS., Dharia, C., Das,K., Galperina, O., Gentz,R., Arnold, E. (2002). Structural Basis of BLyS receptor recognition. Nature Structural Biology,  Apr 9 (4): 288-92.

 

102.      Migone,TS., Zhang,J., Loo,X., Zhuang,L., Chen,C., Hu,B., Hong,JS., Perry,JW., Chen, SF., Zhou,JX., Cho,YH., Ullrich,S., Kanakarai,P., Carrell.J., Boyd,E., Olsen,HS., Hu,G., Pukac,L., Liu,D., Ni,J., Kim,S., Gentz,R., Feng,P., Moore,PA., Ruben,SM., Wei,P. (2002) TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002 Mar,16 (3): 479-92.

 

103.      Sung, C., Nardelli, B.,LaFleur, DW., Blatter, E., Corcoran, M., Olsen, HS., Birse, CE., Pickeral, OK., Zhang, J., Shah, D., Moody, G., Gentz, S., Beebe, L., Moore, PA. (2003). An IFN-beta albumin fusion protein that displays improved pharmacokinetic and pharmacodynamics properties in nonhuman primates.
J Interferon Cytokine Res. Jan; 23(1):25-36.

 

104.      Gentz SH, Bertollo CM, Souza-Fagundes EM, da Silva AM, (2013). Implication of eIF2α kinase GCN2 in induction of apoptosis and endoplasmic reticulum stress-responsive genes by sodium salicylate. Journal of Pharmacy and Pharmacology., Mar;65(3):430-40. doi: 10.1111/jphp.12002. Epub 2012 Nov 19.

 

105.      C.A. Oliveira; C.Velloso-Rodrigues; F.C.J.Machado; B.N.Carvalho; S.H.L.Gentz; O.A.Martins-Filho and D.G.Chaves, (2013). Cytokine profile and FVIII inhibitors development in haemophilia A.  Haemophilia Feb 6. doi: 10.1111/hae.12096.

 

106.      Pimentel, JP; Chaves DG, Araújo AR, de Araújo EM, da Silva Fraporti, Neves WL, Tarragô AM, Torres KL, Gentz SH, Teixeira-Carvalho A, Martins-Filho OA, Malheiro, A. (2013). J Med Virol. Jun; 85(6):1009-18. doi: 10.1002/jmv.23554. Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in haemophilia A patients infected chronically with hepatitis C virus.